Python's Global Interpreter Lock, which determines which single thread can execute native Python code and call C API functions, simplifies writing multithreaded code. By default, the most popular C++ bindings to this API, pybind11 and Cython, implicitly enables the GIL by default. However, sticking with this execution model leaves out extra performance afforded by modern multicore CPUs with hyperthreading, as automatic locking and unlocking of the GIL does not scale well with thread counts, especially in performance-sensitive workloads.
The newfangled free-threaded interpreter promises salvation when running either pure Python code or with compiled extensions. General multithreading rules apply (prefer thread-local variables, using locks to prevent simultaneous access of shared data), but when dealing with projects containing compiled extensions that directly or indirectly interface with Python's C API, more porting rules also apply.
Key porting tips, including projects using the Limited API, include: port native code away from C API functions that avoid borrowed references because they aren't thread-safe; modify unit tests to catch concurrency bugs arising from assuming the presence of the GIL; and extend CI coverage of Python interpreters both for testing and to build free-threaded compatible wheels.